Irrfan Khan, one of India’s most beloved movie stars who also starred in such Hollywood hits as Life of Pi, Slumdog Millionaire and Jurassic World, has died at the age of 53.

Khan, who was diagnosed in March 2018 with a rare neuroendocrine tumor, was hospitalized in Mumbai with a colon infection earlier this week. His death Wednesday comes just days after the death of his mother. Khan had been unable to attend her last rites due to India’s nationwide lockdown from the coronavirus pandemic.

Born in the northern Indian state of Rajasthan, it wasn’t until after more than a decade of playing supporting and character roles that Khan broke into leading roles in the early 2000s, winning his first award for 2004’s Haasil.

Khan rose to international prominence playing a police detective in 2008’s Slumdog Millionaire, then took on the starring role in 2012’s Life of Pi.

Among Khan’s last posts on social media was the following on Twitter on April 8th promoting his final film, Angrezi Medium:

Khan is survived by his wife Sutapa Sikdar and their two sons Babil and Ayan.